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时间: 08-29 20:30
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Brain tissue （right frontal cortical region） was collected on dry ice or RNAlater for drug concentration analysis and Tau qPCR respectively at multiple time points following dosing e.g. 1 week through 16 weeks post-dosing. Animals for Tau qPCR and behavioral studies were adult C57B1/6J female mice （20-30 g; Jackson Laboratories Bar Harbor Me.） housed 3-4 per cage. In some cases male and female transgenic mice （30-40 g） expressing a tau transgene derived from a human PAC H1 haplotype driven by the tau promoter （Polydoro et. In vivo tolerability of the oligomers were tested in mice and rats. The sequence score of the selected oligomers were calculated for further studies. The Sequence score of each oligomer was calculated to predict the suitability of the oligomers. Sequence score is a mathematical calculation determined for all oligomers and is ba |
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时间: 08-29 20:24
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