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Copper-catalyzed coupling of 1a to a substituted iodobenzene 1b or other suitable halo aryl or heteroaryl compound in a suitable solvent such as butanol or dioxane in the presence of a base such as potassium carbonate and a suitable ligand such as NN\‘-dimethylethylenediamine can afford 1-phenylpiperidinones 1c.

Additional methods for this transformation include other variations of Ullmann Goldberg and Buchwald copper-catalyzed amidation or Buchwald Pd-catalyzed amidation depending on the nature of ring B using methods known to one skilled in the art for these types of couplings (see for example Yin & Buchwald Organic Lett.

The present invention provides methods of combination therapy in which an anti-huCD40 antibody is co-administered with one or more additional agents e.g. antibodies that are effective in stimulating immune responses to thereby further enhance stimulate or upregulate immune responses in
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