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In certain embodiments an anti-GPC3 Adnectin comprises the sequence set forth in SEQ ID NO: 3 wherein BC DE and FG loops as represented by （X）.sub.v （X）.sub.x and （X）.sub.z respectively have amino acid sequences at least 75% 80% 85% 90% 95% 97% 98% or 99% identical to the BC DE or FG loop sequences set forth in SEQ ID NOs: 71 72 and 73 respectively. In certain embodiments an anti-GPC3 Adnectin comprises the sequence set forth in SEQ ID NO: 3 wherein BC DE and FG loops as represented by （X）.sub.v （X）.sub.x and （X）.sub.z respectively have amino acid sequences at least 75% 80% 85% 90% 95% 97% 98% or 99% identical to the BC DE or FG loop sequences set forth in SEQ ID NOs: 32 33 and 34 respectively. In some embodiments the anti-GPC3 Adnectin comprises the amino acid sequence set forth in SEQ ID NO: 3 wherein the BC DE and FG loops comprise the amino acid sequences set forth in SEQ ID NOs: 71 72 and 73 respectively wherein the BC loop has 0 1 2 3 4 5 or 6 amino acid s |
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