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4. The chimeric antigen receptor of claim 1 wherein the antibody or antigen binding fragment thereof comprises a VH region comprising the amino acid sequence set forth in SEQ ID NO: 11 or a sequence having at least 90% amino acid sequence identity to SEQ ID NO:11 and a VL region comprising the amino acid sequence set forth in SEQ ID NO: 13 or a sequence having at least 90% amino acid sequence identity to SEQ ID NO:13.
Transl. Medicine 5(215) (December 2013) such as a CAR recognizing an antigen other than CD19 whereby an activating signal delivered through the CD19-targeting CAR is diminished or inhibited by binding of the inhibitory CAR to its ligand e.g. to reduce off-target effects.

The term encompasses genetically engineered and/or otherwise modified forms of immunoglobulins such as intrabodies peptibodies chimeric antibodies fully human antibodies humanized antibodies and heteroconjugate antibodies multispecific e.g. bispecific antibodies diabodies triabodies and tetrabodies tan
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