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Another example of such a combination is an anti-huCD40 antibody in combination with interleukin-2 (IL-2) for the treatment of melanoma.
In all of the above methods CD40 agonism can be combined with other forms of immunotherapy such as cytokine treatment (e.g. interferons GM-CSF G-CSF IL-2) or bispecific antibody therapy which provides for enhanced presentation of tumor antigens. Generally an anti-huCD40 antibody described herein can be combined with (i) an agonist of another co-stimulatory receptor and/or (ii) an antagonist of an inhibitory signal on T cells either of which results in amplifying antigen-specific T cell responses (immune checkpoint regulators).

The present invention provides methods of combination therapy in which an anti-huCD40 antibody is co-administered with one or more additional agents e.g. antibodies that are effective in stimulating immune responses to thereby further enhance stimulate or upregulate immune responses in a subject.
Anti-huCD40 antibodies described herein
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