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Provided are pharmaceutical formulations including the CD19-binding molecule e.g. antibody or chimeric receptor and/or the engineered cells expressing the molecules. Also provided are molecules such as chimeric and/or fusion molecules including receptors such as recombinant receptors that include the antibody of any of the embodiments （e.g. contained in or part of an extracellular domain） and additional domains such as intracellular signaling domains spacers li In particular embodiments the antibody or fragment comprises a VH region comprising the amino acid sequence of SEQ ID NO: 61 or a sequence having at least or at least about 90% 91% 92% 93% 94% 95% 96% 97% 98% or 99% amino acid sequence identity thereto. 17. The chimeric antigen receptor of claim 16 wherein the intracellular signaling domain further comprises an intracellular signaling region of a T cell costimulatory molecule. In some embodiments the CAR or other antigen receptor further inclu |
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