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In particular embodiments about 1.times.10.sup.7 CAR T cells to about 1.times.10.sup.9 CAR T cells about 2.times.10.sup.7 CAR T cells to about 0.9.times.10.sup.9 CAR T cells about 3.times.10.sup.7 CAR T cells to about 0.8.times.10.sup.9 CAR T cells about 4.times.10.sup.7 CAR T cells to about 0.7.times.10.sup.9 CAR T cells about 5.times.10.sup.7 CAR T cells to about 0.6.times.10.sup.9 CAR T cells or about 5.times.10.sup.7 CAR T cells to about 0.5.times.10.sup.9 CAR T cells are administered to a subject. In one embodiment the compositions contemplated herein are administered to a subject by direct injection into a tumor lymph node or site of infection. One of ordinary skill in the art would recognize that multiple administrations of the compositions of the invention may be required to effect the desired therapy. The purpose of this experiment was to determine the effect of Akt inhibitors on T cell proliferation. The purpose of this experiment was to determine the effect of Akt inhibitors on T cell m |
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