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It is well known that complementarity is the base principle of DNA replication and transcription as it is a property shared between two DNA or RNA sequences such that when they are aligned antiparallel to each other the nucleotide bases at each position in the sequences will be complementary much like looking in the mirror and seeing the reverse of things.
The term "design" or "oligomer design" or "ASO Sequence" as used herein refers to a pattern of nucleotides (e.g. DNA) and nucleotide analogs (e.g. LNA) in a given sequence. The term "chemical structure" of an oligomer as used herein refers to a detailed description of the components of the oligomers e.g. nucleotides (e.g. DNA) nucleotide analogs (e.g. beta-D-oxy-LNA) nucleotide base (e.g. A T G C U or MC) and backbone structure (e.g. phosphorothioate or phosphorodiester).
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